L-2-HGA (L-2-hydroxyglutaric aciduria) in Staffordshire Bull Terriers is a neurometabolic disorder characterised by elevated levels of L-2-hydroxyglutaric acid in urine, plasma and cerebrospinal fluid.
L-2-HGA affects the central nervous system, with clinical signs usually apparent between 6 months and 1 year (although they can appear later). Symptoms include epileptic seizures, "wobbly" gait, tremors,
muscle stiffness as a result of exercise or excitement and altered behaviour. The mutation, or change to the structure of the gene, probably occurred spontaneously in a single dog but once in the population
has been inherited from generation to generation like any other gene. The disorder shows an autosomal recessive mode of inheritance: two copies of the defective gene (one inherited from each parent) have
to be present for a dog to be affected by the disease. Individuals with one copy of the defective gene and one copy of the normal gene - called carriers - show no symptoms but can pass the defective gene onto
their offspring. When two apparently healthy carriers are crossed, 25% (on average) of the offspring will be affected by the disease, 25% will be clear and the remaining 50% will themselves be carriers.
The mutation responsible for the disease has recently been identified at the Animal Health Trust. Using the information from this research, we have developed a DNA test for the disease. This test not only
diagnoses dogs affected with this disease but can also detect those dogs which are carriers, displaying no symptoms of the disease but able to produce affected pups. Carriers could not be detected by the tests
previously available which involved either a blood or urine test detecting elevated levels of L-2-hydroxyglutarate or magnetic resonance imaging. Under most circumstances, there will be a much greater number
of carriers than affected animals in a population. It is important to eliminate such carriers from a breeding population since they represent a hidden reservoir of the disease that can produce affected dogs at any
time. The test is available now and information on submitting samples is given below.
Breeders will be sent results identifying their dog as belonging to one of three categories:
CLEAR: the dog has two copies of the normal gene and will neither develop L-2-HGA, nor pass a copy of the L-2-HGA gene to any of its offspring.
CARRIER: the dog has one copy of the normal gene and one copy of the mutant gene that causes L-2-HGA. It will not develop L-2-HGA but will pass on the L-2-HGA gene to 50%(on average)of its offspring.
AFFECTED: the dog has two copies of the L-2-HGA mutation and is affected with L-2-HGA. It will develop L-2-HGA at some stage during its lifetime, assuming it lives to an appropriate age.
Carriers can still be bred to clear dogs. On average, 50% of such a litter will be clear and 50% carriers; there can be no affected pups produced from such a mating. Pups which will be used for breeding can
themselves be DNA tested to determine whether they are clear or carrier. Courtesy AHT
HEREDITARY CATARACTS (also called Juvenile Cataracts) Hereditary Cataract in Staffordshire Bull Terriers has been recognised as an inherited condition since the late 1970's. Affected dogs develop cataracts
in both eyes at an early age. The condition is not congenital, so the lenses are normal at birth but cataracts appear at a few weeks to months in age, progressing to total cataract (and resulting blindness) by 2
to 3 years of age. The mutation, or change to the structure of the gene, probably occurred spontaneously in a single dog but once in the population has been inherited from generation to generation like any
other gene. The disorder shows an autosomal recessive mode of inheritance: two copies of the defective gene (one inherited from each parent) have to be present for a dog to be affected by the disease.
Individuals with one copy of the defective gene and one copy of the normal gene - called carriers - show no symptoms but can pass the defective gene onto their offspring. When two apparently healthy carriers
are crossed, 25% (on average) of the offspring will be affected by the disease, 25% will be clear and the remaining 50% will themselves be carriers. The mutation responsible for the disease has recently been
identified at the Animal Health Trust. Using the information from this research, we have developed a DNA test for the disease. This test not only diagnoses dogs affected with the disease but can also detect
those dogs which are carriers, displaying no symptoms of the disease but able to produce affected pups. Under most circumstances, there will be a much greater number of carriers than affected animals in a
population. It is important to eliminate such carriers from a breeding population since they represent a hidden reservoir of the disease that can produce affected dogs at any time. The test is available now and
information on submitting samples is given below. Breeders will be sent results identifying their dog as belonging to one of three categories:
CLEAR: the dog has two copies of the normal gene and will neither develop Hereditary Cataract, nor pass a copy of the Hereditary Cataract gene to any of its offspring.
CARRIER: the dog has one copy of the normal gene and one copy of the mutant gene that causes Hereditary Cataract. It will not develop Hereditary Cataract but will pass on the Hereditary Cararact gene to
50% (on average) of its offspring.
AFFECTED: the dog has two copies of the Hereditary Cataract mutation and is affected with Hereditary Cataract. It will develop Hereditary Cataract at some stage during its lifetime, assuming it lives to an
appropriate age. Carriers can still be bred to clear dogs. On average, 50% of such a litter will be clear and 50% carriers; there can be no affected pups from such a mating. Pups which will be used for
breeding can themselves be DNA tested to determine whether they are clear or carrier. Courtesy AHT
PERSISTENT HYPERPLASTIC PRIMARY VITREOUS (PHPV) - This is a congenital condition (present from birth) in which there is a developmental defect in the normal regression of some of the intraocular
structures of the eye. PHPV can range from being very mild to severe abnormalities which may lead to blindness. The presence of mild abnormalities are usually seen as small brown pigmented dots on the
posterior lens capsule. Previously the literature indicated that this was always observed as a bilateral phenomenon but recently it has been stated that affected dogs may show unilateral involvement, although
this is less common. The present knowledge of the mode of inheritance of this disease is thought to be an autosomal irregular dominant with variable expression. Due to PHPV seldom resulting in secondary
cataracts in the stafford,those that are mildly afflicted will seldom show any form of visual impairment during the course of their lives. Even those that are more severly afflicted, may be capable of adapting by
using peripheral to compensate. Stafford breeders should therefore not assume that the problem is absent simply because they have not encountered blatant signs of visual impairment, instead discerning
breeders should ensure that all their Staffords are tested through the National Eye Scheme.
DISTICHIASIS - Sometimes the condition is referred to as a doudle row of eyelashes, for extra hairs arise from the edge of the eye lid to rub against the corneal surface. The effects are variable and mild
irritation to corneal ulceration will be seen. Treatment is extremely difficult and invariably involves surgery to remove the hair roots permanently. Plucking out the offending hairs is useful, but requires the
maximum cooperation of the patient! Of course it is followed by hair regrowth, and many surgical techniques have been invented to remove the roots. Even then success is difficult to achieve, and the dog may
have to suffer this condition throughout its life. It is the most common eye defect found in the Stafford in South Africa.
ENTROPIAN - Primarily an inherited condition. It is due to an excess of eyelid tissue, or a small eye, or both, the result being that a varying amount of hair-covered eyelid can turn in to rub directly against the
cornea or conjunctiva, or both. It is usually extremely painfull ,and the damage caused to the cornea can render the eye blind. Most dogs are affected by six months of age and in some the signs of the problem
(excessive blinking and a wet face)may be seen within the first month of life. Occasionally the condition is self-correcting as the puppy grows, but in the vast majority of affect dogs surgery is necessary to turn
the eyelid away from the surface of the eye. Usually such surgery is successful, but it is much better that, as with the other inherited eyelid defects, breeders try to avoid producing this condition in their stock.
Hip Dysplasia - Hip Dysplaysia is a terrible genetic disease because of the various degrees of arthritis ( also called degenerative joint disease, arthrosis, osteoarthrosis ) it can eventually produce, leading to pain and debilitation. The very first step in the development of arthritis is articular cartilage ( the type of cartilage lining the joint ) damage due to the inherited bad biomechanics of an abnormally developed hip joint. Traumatic articular fracture through the joint surface is another way cartilage is damaged. With cartilage damage, lots of degradative enzymes are released into the joint. These enzymes degrade and decrease the synthesis of important constituent molecules that form hyaline cartilage called proteoglycans. This causes the cartilage to lose its thickness and elasticity, which are important in absorbing mechanical loads placed across the joint during movement. Eventually, more debris and enzymes spill into the joint fluid and destroy molecules called glycosaminoglycan and hyaluronate which are important precursors that form the cartilage proteoglycans. The joints lubrication and ability to block inflammatory cells are lost and the debris-tainted joint fluid loses its ability to properly nourish the cartilage through impairment of nurtient-waste exchange across the joint cartilage cells. The damage then spreads to the synovial membrane lining the joint capsule and more degradative enzymes and inflammatory cells stream into the joint. Full thickness loss of cartilage allows the synovial fluid to contact nerve endings in the subchondral bone, resulting in pain. In an attempt to stabilize the joint to decrease the pain, the animal's body produces new bone at the edges of the joint surface, joint capsule, ligament and muscle attachments (bone spurs). The joint capsule also eventually thickens and the joint's range of motion decreases. No one can predict when or even if a dysplastic dog will start showing clinical signs of lameness due to pain. There are multiple environmental factors such as caloric intake, level of exercise, and weather that can affect the severity of clinical signs and phenotypic expression (radiographic changes). There is no rhyme or reason to the severity of radiographic changes correlated with the clinical findings. There are a number of dysplastic dogs with with severe artheritis that run, jump, and play as if nothing is wrong and some dogs with barely any artheritic radiographic changes that are severely lame. Courtesy OFA
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